(1) The mechanism of the tRNA modification and aminoacylation

(2) The mechanism of bacterial defense systems and its application

Research Projects

National Natural Science Foundation of China, 2023 (General Project)

National Natural Science Foundation of China, 2021 (Youth Project)

1.Yang, H.; Yan, R.X.; Li, Y.; Lu, Z.X.; Bie, X.M.; Zhao, H.Z.; Lu, F.X.*; Chen, M.R.* Structure–Function Analysis of a Quinone-Dependent Dehydrogenase Capable of Deoxynivalenol Detoxification. Journal of Agricultural and Food Chemistry, 2022; 70: 6764-6774. (IF: 5.895)

2. Du, H.C.; Chi, H.B.; Yao, H.L.; Lu, Z.X.; Bie, X.M.; Zhang, C.; Zhao, H.Z.; Lu, F.X.*; Chen, M.R.* The antibacterial activity of plantaricin GZ1–27 against MRSA and its bio-preservative effect on chilled pork in combination with chitosan. International Journal of Food Microbiology, 2022; 365, 109539. (IF: 5.911)

3. Gao, H.; Niu, J.F.; Yang, H.; Lu, Z.X.; Zhou, L.B.; Meng, F.Q.; Lu, F.X.*; Chen, M.R.* Epimerization of deoxynivalenol by the Devosia strain A6-243 assisted by pyrroloquinoline quinone. Toxins, 2021;14, 16. (IF: 5.075)

4. Niu, J.F.; Meng, F.Q.; Zhou, Y.W.; Zhang, C.; Lu, Z.X.; Lu, F.X.*; Chen, M.R.* Non-classical secretion of a type I L-asparaginase in Bacillus subtilis. International Journal of Biological Macromolecules, 2021; 180: 677-683. (IF: 8.025)

5. Chen, M.R; Kuhle, B.; Diedrich, J.; Liu, Z.; Moresco, J.; Yates, J.; Pan, T.; Yang, X.L.* Cross-editing by a tRNA synthetase allows vertebrates to abundantly express mischargeable tRNA without causing mistranslation. Nucleic Acids Research, 2020; 48: 6445-6457. (IF: 16.971)

6. Chen, M.R.#; Gai, Z.Q#; Okada, C.; Ye, Y.X.; Yu, J.; Yao, M* FlexibleNAD+ Binding in deoxyhypusine synthase reflects the dynamic hypusine modification of translation factor IF5A. International Journal of Molecular Sciences, 2020; 21:5509. (IF: 5.923)

7. Ye, Y.X.#; Chen, M.R.#; Kato, K.; Yao, M.* The pH-dependent conformational change of eukaryotic translation initiation factor 5: Insights into partner-binding manner, Biochemical and Biophysical Research Communications, 2019; 519: 186-191. (IF: 2.985)

8. Sun, X.M.#; Chen, M.R.#; Jia, F.; Hou, Y.; Hu, S.Q.* Crystal structure of wheat glutaredoxin and its application in improving processing quality of flour. Journal of Agricultural and Food Chemistry, 2018; 66: 12079-12087. (IF: 3.571)

9. Chen, M.R.; Kato, K.; Kubo, Y.; Tanaka, Y.; Liu, Y.C.; Long, F.; Whitman, WB.; Lill, P.; Gatsogiannis, C.; Raunser, S.; Shimizu, N.; Shinoda, A.; Nakamura, A.; Tanaka, I.; Yao, M.* Structural basis for tRNA-dependent cysteine biosynthesis. Nature Communications, 2017; 8: 1521. (IF: 12.353)

10. Chen, M.R.; Nakazawa, Y.; Kubo, Y.; Asano, N.; Kato, K.; Tanaka, I.; Yao, M.*, Crystallographic analysis of a subcomplex of transsulfursome with tRNA for Cys-tRNACys synthesis. Acta Crystallographica Section F: Structural Biology Communications, 2016; 72: 569-572. (IF: 0.95)