Molecular Mechanism and Drug Research of Liver Diseases

Transcriptional regulation of drug metabolizing enzy

Research Projects

1. National Natural Science Foundation of China (youth project), 81503150, 2016/01-2018/12.

2. Natural Science Foundation of Jiangsu Province (youth project), BK20130657, 2013/07-2016/06.

3. Fundamental Research Funds for the Central Universities (key project), 2632019ZD05, 2019/01-2020/12.

4. Stater Key Laboratory of Natural Medicines, ZJ11176, 2011/12-2013/12.

1. Wang, Y.Z.; Wang Y.L.; Che H.J.; Jia Y.H.; Wang H.F.; Zuo L.F.; Yang K.; Li T.T.^*; Wang J.X.^* Sappanone A: A natural PDE4 inhibitor with dual anti-inflammatory and antioxidant activities from the heartwood of Caesalpinia sappan L. J Ethnopharmacol. 2023;304:116020. (IF: 5.195)

2. Li, T.T.^*; Zheng, R.Y.; Xu, L.J.; Zhou, M.X.; Wang, X.J.; Qianqian Guo, Q.Q.; Hui Ji, H.; Li, L.W^*. Picroside II alleviates liver injury induced by alpha-naphthylisothiocyanate through AMPK-FXR pathway. Toxicol Appl Pharmacol. 2020;408:115248. (IF: 3.347)

3. Xu, L.J.; Zheng, R.Y.; Xie, P.; Guo, Q.Q.; Ji, H.; Li, T.T.^* Dysregulation of UDP-glucuronosyltransferases in CCl4 induced liver injury rats. Chem Biol Interact. 2020;325:109115. (IF: 3.723)

4. Li, T.T.; Xu, L.J.; Zheng, R.Y.; Wang, X.J.; Li, L.W.; Ji, H.^*, Hu Q.H.^* Picroside II protects against cholestatic liver injury possibly through activation of farnesoid X receptor. Phytomedicine. 2020;68:153153. (IF: 4.268)

5. Li, T.T.; Jiang, S.D.; Ni, B.W.; Cui, Q.J.; Liu, Q.N.; Zhao, H.P.^* Discontinued Drugs for the Treatment of Cardiovascular Disease from 2016 to 2018. Int J Mol Sci. 2019; 20: 4513. (IF: 4.183)

6. Wang, W.S.; Ji, H.^*; Li, T.T.^*; Jia, Y.W.; Xie, H.T. Pharmacokinetic comparisons of S-oxiracetam   and R-oxiracetam in beagle dogs. Acta Pharm. 2016, 66: 279-287. (IF: 1.212)

7. Li, T.T.; Hua, K.; Sheng, X.; Liu, L.; Tan, J.N.; Wang, L.N.; Wei, B.; Ji, H.^*; Zhang, Y.H.^* An HPLC method for the quantitation of 3-pentylbenzo[c]thiophen-1(3H)-one in dog plasma and its application to a pharmacokinetic study. Biomed Chromatogr. 2014, 28: 1592-1596. (IF: 1.723)

8. Liu, L.^#; Li, T.T.^#; Tan, J.N.; Fu, J.J.; Guo, Q.Q.; Ji, H.^*; Zhang, Y.H.^* NG as a novel nitric oxide donor induces apoptosis by increasing reactive oxygen species and inhibiting mitochondrial function in MGC803 cells. Int Immunopharmacol. 2014, 23: 27-36. (Co-first author) (IF: 2.711)

9. Wang, X.L. ^#; Wang, L.N. ^#; Li, T.T.^#; Huang, Z.J.; Lai, Y.S.; Ji, H.^*; Wan, X.L.; Xu, J.Y. ^*; Tian, J.D.; Zhang, Y.H.^* Novel hybrids of optically active ring-opened 3-n-butylphthalide derivative and isosorbide as potential anti-ischemic stroke agents. J Med Chem. 2013, 56 (7) : 3078-3089. (Co-first author) (IF: 5.4)