(1) Study on the Development and Application of Electrochemical Sensors
(2) Research on New Materials and Methods for Drug Analysis
1. Research Projects
(1) National Natural Science Foundation of China, General Project, No.21275162, Construction of Vesicular Electrochemical Sensor and Its Application in Drug Cell Membrane Affinity Screening Model, 2013-01-01 to 2016-12-31, presided over
(2) National Natural Science Foundation of China, General Project, No.21075108, Study on the Detection of Antibiotic Residues in Animal Derived Foods Using Electrochemical Immunosensors, 2011-01-01 to 2013-12-31, presided over
(3) Young and middle-aged academic leader of the Blue Blue Project in Jiangsu Province, 2012-12 to 2015-12, presided over
(4) School-enterprise cooperation project, performance testing and application research of anti-corrosion wax, 2019-09 to 2020-08, presided over
(5) School-enterprise cooperation project, high performance liquid chromatography electrochemical determination of catecholamines and their methoxy metabolites in urine, 2016-10 to October 2017-10, presided over
2. Representative Research Achievements
(1) The development of electrochemical immunosensors based on nanomaterials, which performed the high selectivity and sensitivity for the detection and analysis of tumor markers and viruses, was of great significance for the clinical research and diagnosis of tumors and the diagnosis and treatment of other diseases. It also provided a novel and sensitive method for the detection of various life related substances.
(2) A simple, rapid and accurate method for the determination of four electrochemically active components in human urine from patients with pheochromocytoma, namely norepinephrine, epinephrine, norbenzyl epinephrine and m-norepinephrine, was established by solid phase extraction and high performance liquid chromatography with electrochemical detection, providing a basis for the diagnosis of chromaffin tumors and a relatively simple, rapid effective analytical methods.
1. Zhang, X.L.; Qi, J.L.; Zhang, Q.Y.; Xue, Y.; Meng, F.; Zhang, J.Y.; Liu, Y.H.; Yang, G.J.* Wu, C.Y. A novel sandwich impedimetric immunosensor for detection of apolipoprotein‐A1 based on the gold nanoparticle–hybridized mercapto‐β‐cyclodextrin‐Pb(II) metal–organic framework, Microchim. Acta, 2023, 190:33 (IF:6.408)
2. Qi, J.L.; Zhang, X.L.; Zhang, Q.Y.; Xue, Y.; Meng, F.; Liu, Y.H.*; Yang, G.J.* Ultrasensitive “signal-on” sandwich electrochemiluminescence immunosensor based on Pd@Au-L-cysteine enabled multiple-amplification strategy for Apolipoprotein-A1 detection, Microchem J. 2022, 178: 107409. (IF:4.821)
3. Sun, J.; Hang, T.J.; Cao, L.; Fan, X.L.; Feng, Y.L.; Tan , l.; Wamg, Q.Y.; Liu, Y.X.; Yang, G.J.* Assessment of polybrominated diphenyl ethers and emerging brominated flame retardants in Pheretima (a Traditional Chinese Medicine): occurrence, residue profiles, and potential health risks. Environ Pollut. 2021, 276:116680. (IF:9.988)
4. Zhang, X.L.; Qi, J.L.; Feng, F.*; Yang, G.J.* Study of ethosuximide detection using a novel molecularly imprinted electrochemiluminescence sensor based on tris(2,2’-bipyridyl) ruthenium (II)@nitrogen doped graphene quantum dots. J Electroanal Chem. 2020, 874: 114455. (IF:4.464)
5. Li, X.T.; Wang. Y.C.; Zhang, X.L.; Gao, Y.; Sun, C.M.; Ding, Y.H.; Feng, F.*; Jin, W.J.*; Yang, G.J.* An impedimetric immunosensor for determination of porcine epidemic diarrhea virus based on the nanocomposite consisting of molybdenum disulfide/reduced graphene oxide decorated with gold nanoparticles. Microchim Acta. 2020, 187:217. (IF:5.833)
6. Zhang, X.L.; Li, X.; Li, X.T.; Gao, Y.; Feng, F.*; Yang, G.J.* Electrochemiluminescence sensor for pentoxifylline detection using Au nanoclusters@graphene quantum dots as an amplified electrochemiluminescence luminophore. Sensor Actuator B. 2019, 282: 927-935. (IF:7.460)
7. Wang, X.Y.; Shen, W.Y.; Zhang, X.L., Guo, S.Y.; Gao, Y.; Li, X.T.; Feng, F.*; Yang, G.J.* Indirect electrochemical determination of ribavirin using boronic acid-diol recognition on a 3-aminophenylboronic acid-electrochemically reduced Ggraphene oxide modified glassy carbon electrode (APBA/ERGO/GCE), Anal Lett. 2019, 52: 1900–1913. (IF:1.5)
8. Hou, XS.; Wang, H.S.; Mugaka, B.P.; Yang, G.J.*, Ding, Y*. Mitochondria: promising organelle targets for cancer diagnosis and treatment. Biomater Sci. 2018, 6: 2786-2797. (IF:5.8)
9. Yao, S.Y.; Cai, W.L.; Liu, L.; Liao. X.Q.; Feng, F.*; Yang, G.J.* Electrochemical behavior of eriocitrin and high sensitive determination based on the electrochemically reduced graphene oxide modified glassy carbon electrode. Anal Methods. 2016, 8: 3722–3729
10. Cai, W.L.; Liu, L.; Liao, X.Q.; Tao, K.L.; Feng, F.*; Yang, G.J.* Determination of eriodictyol by a multiwalled carbon nnotube modified glassy carbon electrode. Anal Lett. 2016, 49:1502-1512 (IF:1.2)
