(1) Method development for multi-mode chromatography-mass spectrometry in metabolomics.

(2) Method development for active component-effect correlation analysis of traditional Chinese medicine.

1. Research Projects

(1)The Open Project Program of MOE Key Laboratory of Drug Quality Control and Pharmacovigilance (DQCP20/21PQ07): Study on material basis and mechanism of Qifu decoction on heart failure based on mitochondrial proteomics and magnetic bead-assisted fishing assay as well as molecular docking, 2021/04-2023/04.

(2)The Fundamental Research Funds for the Central Universities (2632020ZD06):  Study on the protective mechanism of hypoxic preconditioning against hypoxic nerve injury, 2020/01-2021/12.

(3)The National Natural Science Foundation of China (81301685): Neuroprotective endogenous mediators and the regulatory network triggered by hypoxic preconditioning, 2014/01-2016/12.

1. Chunxia Zhang^#, Zhen Xue^#, Lingmeng Zhu, Jiayu Zhou, Lingxin Zhuo, Jiayi Zhang, Xinchen Zhang, Wenyuan Liu*, Lingfei Han*, Wenting Liao*. Rhynchophylline alleviates neuroinflammation and regulates metabolic disorders in a mouse model of Parkinson's disease. Food & Function, 2023, doi: 10.1039/d2fo02939a. (IF=6.317)

2.Xin Ding^#, Ya Zhang^#, Pengchao Pan^#, Cuiping Long, Xingxing Zhang, Lingxin Zhuo, Qian Zhou*, Wenting Liao*, Guangguo Tan*. Multiple mitochondria-targeted components screened from Sini decoction improved cardiac energetics and mitochondrial dysfunction to attenuate doxorubicin-induced cardiomyopathy. Theranostics, 2023, 13(2):510-530. (IF=11.600)

3.Zhen Xue^#, Lingxin Zhuo^#, Bowen Zhang, Lingmeng Zhu, Xinran Xiang, Chunxia Zhang, Wenyuan Liu*, Guangguo Tan*, Wenting Liao*. Untargeted metabolomics reveals the combination effects and mechanisms of Huangqi-fuzi herb-pair against doxorubicin-induced cardiotoxicity. Journal of Ethnopharmacology, 2023, 305:116109. (IF=5.195)

4.Wenting Liao^#, Qiwen Jin^#, Junning Liu, Yiling Ruan, Xinran Li, Yueyue Shen, Zhicheng Zhang, Yong Wang, Shengming Wu, Junying Zhang, Lifeng Kang, Chunyong Wu*. Mahuang Decoction antagonizes acute liver failure via modulating tricarboxylic acid cycle and amino acids metabolism. Frontiers in Pharmacology, 2021, 12: 599180. (IF=5.810)

5.Wenting Liao, Jie Liu, Siming Wang, Zhen Xue, Feng Zheng, Feng Feng, Wenyuan Liu*. Metabolic profiling reveals that salidroside antagonizes hypoxic injury via modulating energy and lipid metabolism in cardiomyocytes. Biomedicine & Pharmacotherapy, 2020, 122:109700. (IF=4.545)

6.Wenting Liao, Zhen Xue, Xin Wang, Yidan Bai, Yue Xiao, Feng Zheng, Feng Feng, Wenyuan Liu*. Metabolic profiling deciphering the potential targets of Yi-Gan San against vascular dementia in rat. Brain Research, 2020, 1727, 146512. (IF= 3.125)

7.Wenting Liao^#, Jie Liu^#, Simin Zhou, Gang Xu Yuqi Gao*, Wenyuan Liu*. UHPLC-QTOFMS-based metabolomic analysis of the hippocampus in hypoxia preconditioned mouse. Frontiers in Physiology, 2019, doi: 10.3389/fphys.2018.01950. (IF=3.367)

8.Guangguo Tan^#, Xin Wang^#, Kui Liu, Xin Dong, Wenting Liao*, Hong Wu*. Correlation of drug-induced and drug-related ultra-high performance liquid chromatography-mass spectrometry serum metabolomic profiles yields discovery of effective constituents of Sini decoction against myocardial ischemia in rats. Food＆ Function, 2018, 9(11):5528-5535. (IF=4.171)

9.Guangguo Tan^#, Qian Zhou^#, Kui Liu, Xin Dong, Ling Li, Wenting Liao*, Hong Wu*. Cross-platform metabolic profiling deciphering the potential targets of Shenfu injection against acute viral myocarditis in mice. Journal of Pharmaceutical and Biomedical Analysis, 2018, 160:1-11. (IF= 3.169)

10.Wenting Liao, Bao Liu, Jian Chen, Jianhua Cui, Yixing Gao, Fuyu Liu, Gang Xu, Bingda Sun, Erlong Zhang, Zhibin Yuan, Gang Zhang*, Yuqi Gao*. Metabolite modulation in human plasma in the early phase of acclimatization to hypobaric hypoxia. Scientific Reports, 2016, 6:22589. (IF=5.228)