(1) 小分子抗肿瘤创新药物研发
(2) 致病蛋白降解药物的研发

1、科研项目
（1）国家自然科学基金委员会，青年项目，82103989，新型“变构-共价”双功能GLS1抑制剂的设计、合成与抗肿瘤活性研究，2022-01-01 至 2024-12-31，30万元，在研，主持
（2）中国博士后科学基金，面上项目，2020M681789，靶向肿瘤能量代谢谷氨酰胺酶变构位点的小分子共价抑制剂的研究，2021-01 至 2023-06，8万元，在研，主持
（3）江苏省资助招收博士后研究人员，16万元，主持
2、学术获奖
（1）2021-12，江苏省优秀博士学位论文

1.Yan Li, Ya Chua, Guangjiang Shia, Xiaobin Wang, Wanli Ye, Chun Shan, Dajia Wang, Di Zhang, Wei He, Jingwei Jiang, Shuqian Ma, Yuhong Han, Zhili Zhao, Shijia Du, Zhen Chen, Zhiyu Li, Yong Yang, Chen Wang*, Xi Xu*, Hongxi Wu*. A novel inhibitor of ARfl and ARv7 induces protein degradation to overcome enzalutamide resistance in advanced prostate cancer. Acta Pharmaceutica Sinica B. DOI: 10.1016/j.apsb.2022.05.003. (IF = 14.903)
2.Xi Xu, Xiujin Chang, Jingxuan Huang, Di Zhang, Min Wang, Tian Jing, Yu Zhuang, Junping Kou, Zhixia Qiu, Jubo Wang, Zhiyu Li*, Jinlei Bian*. Discovery of novel glutaminase 1 allosteric inhibitor with 4-piperidinamine linker and aromatic heterocycles. European Journal of Medicinal Chemistry, 2022, 236: 114337. (IF = 7.088)
3.Xi Xu, Di Zhang, Tengteng Zhao, Min Wang, Yu Li, Qianming Du, Junping Kou, Zhiyu Li*, Jinlei Bian*. Novel biphenyl-based scaffold as potent and selective histone deacetylase 6 (HDAC6) inhibitors: Identification, development and pharmacological evaluation. European Journal of Medicinal Chemistry, 2022, 233: 114228. (IF = 7.088)
4.Youquan Xie, Yucheng Tian, Yuming Zhang, Zhisheng Zhang, Rui Chen, Mian Li, Jiawei Tang, Jinlei Bian, Zhiyu Li*, Xi Xu*. Overview of the development of selective androgen receptor modulators (SARMs) as pharmacological treatment for osteoporosis (1998-2021). European Journal of Medicinal Chemistry, 2022, 230: 114119. (IF = 7.088)
5.Xi Xu, Jubo Wang, Min Wang, Xinyu Yuan, Lei Li, Chao Zhang, Huidan Huang, Tian Jing, Chenchen Wang, Chao Tong, Liwen Zhou, Ying Meng, Pengfei Xu, Junping Kou, Zhixia Qiu, Zhiyu Li, Jinlei Bian. Structure-Enabled Discovery of Novel Macrocyclic Inhibitors Targeting Glutaminase 1 Allosteric Binding Site. Journal of Medicinal Chemistry, 2021, 64, 4588-4611. (IF = 7.446)
6.Xi Xu, Qianming Du, Ying Meng; Zhiyu Li, Hongxi Wu, Yan Li, Zhili Zhao, Raoling Ge, Xiaoyu Lu, Siqi Xue, Xijing Chen, Yong Yang, Jubo Wang, Jinlei Bian. Discovery of pyridine tetrahydroisoquinoline thiohydantoin derivatives with low blood-brain barrier penetration as the androgen receptor antagonists, European Journal of Medicinal Chemistry, 2020, 192: 112196. (IF = 5.572)
7.Xi Xu, Zijian Kuang, Jie Han, Ying Meng, Lei Li, Hongyu Luan, Pengfei Xu, Jubo Wang, Cheng Luo, Hong Ding, Zhiyu Li, Jinlei Bian. Development and Characterization of a Fluorescent Probe for GLS1 and the Application for High-Throughput Screening of Allosteric Inhibitors. Journal of Medicinal Chemistry, 2019, 62, 9642-9657. (IF = 6.054)
8.Xi Xu, Ying Meng, Lei Li, Pengfei Xu, Jubo Wang, Zhiyu Li, Jinlei Bian. Overview of the Development of Glutaminase Inhibitors: Achievements and Future Directions. Journal of Medicinal Chemistry, 2019, 62 (3) 1096-1115. (IF = 6.054)
9.Xi Xu, Raoling Ge, Lei Li, Jubo Wang, Xiaoyu Lu, Siqi Xue, Xijing Chen, Zhiyu Li, Jinlei Bian. Exploring the tetrahydroisoquinoline thiohydantoin scaffold blockade the androgen receptor as potent anti-prostate cancer agents. European Journal of Medicinal Chemistry, 2018, 143, 1325-1344. (IF = 4.816)

李志裕教授团队成员