(1) 肝脏疾病的分子机制与药物研究
(2) 药物代谢酶的转录调控

科研项目
（1）国家自然科学基金青年项目，81503150，基于FXR-UGT研究胡连苷II治疗瘀胆型肝炎的作用机制，2016-01至2018-12，17.9万元，已结题，主持
（2）江苏省自然科学基金青年基金项目，BK20130657，胡黄连苷II调控UGTs的保肝作用及机制研究，2013-07至2016-06，20万元，已结题，主持
（3）中央高校基本业务费重点项目，2632019ZD05，基于AMPK通路胆汁酸代谢调控的胡黄连苷II抗胆汁淤积机制研究，2019-01至2020-12，15万元，已结题，主持。
（4）“天然药物活性组分与药效”国家重点实验室培育项目，ZJ11176，丁苯酞衍生物和类似物的化学与生物学研究，2011-12至2013-12，15万元，已结题，主持。

1.Li, T.T.*; Zheng, R.Y.; Xu, L.J.; Zhou, M.X.; Wang, X.J.; Qianqian Guo, Q.Q.; Hui Ji, H.; Li, L.W*. Picroside II alleviates liver injury induced by alpha-naphthylisothiocyanate through AMPK-FXR pathway. Toxicol Appl Pharmacol. 2020;408:115248. (IF: 3.347)
2.Xu, L.J.; Zheng, R.Y.; Xie, P.; Guo, Q.Q.; Ji, H.; Li, T.T.* Dysregulation of UDP-glucuronosyltransferases in CCl4 induced liver injury rats. Chem Biol Interact. 2020;325:109115. (IF: 3.723)
3.Li, T.T.; Xu, L.J.; Zheng, R.Y.; Wang, X.J.; Li, L.W.; Ji, H.*, Hu Q.H.* Picroside II protects against cholestatic liver injury possibly through activation of farnesoid X receptor. Phytomedicine. 2020;68:153153. (IF: 4.268)
4.Li, T.T.; Jiang, S.D.; Ni, B.W.; Cui, Q.J.; Liu, Q.N.; Zhao, H.P.* Discontinued Drugs for the Treatment of Cardiovascular Disease from 2016 to 2018. Int J Mol Sci. 2019; 20: 4513. (IF: 4.183)
5.Wang, W.S.; Ji, H.*; Li, T.T.*; Jia, Y.W.; Xie, H.T. Pharmacokinetic comparisons of S-oxiracetam   and R-oxiracetam in beagle dogs. Acta Pharm. 2016, 66: 279-287. (IF: 1.212)
6.Li, T.T.; Hua, K.; Sheng, X.; Liu, L.; Tan, J.N.; Wang, L.N.; Wei, B.; Ji, H.*; Zhang, Y.H.* An HPLC method for the quantitation of 3-pentylbenzo[c]thiophen-1(3H)-one in dog plasma and its application to a pharmacokinetic study. Biomed Chromatogr. 2014, 28: 1592-1596. (IF: 1.723)
7.Liu, L.#; Li, T.T.#; Tan, J.N.; Fu, J.J.; Guo, Q.Q.; Ji, H.*; Zhang, Y.H.* NG as a novel nitric oxide donor induces apoptosis by increasing reactive oxygen species and inhibiting mitochondrial function in MGC803 cells. Int Immunopharmacol. 2014, 23: 27-36. (Co-first author) (IF: 2.711)
8.Wang, X.L. #; Wang, L.N. #; Li, T.T.#; Huang, Z.J.; Lai, Y.S.; Ji, H.*; Wan, X.L.; Xu, J.Y. *; Tian, J.D.; Zhang, Y.H.* Novel hybrids of optically active ring-opened 3-n-butylphthalide derivative and isosorbide as potential anti-ischemic stroke agents. J Med Chem. 2013, 56 (7) : 3078-3089. (Co-first author) (IF: 5.4)