1.活性天然产物的全合成、结构修饰和生物学评价研究：
针对具有强生物活性的天然产物如生物碱类、环状萜类，开展活性天然产物的全合成、结构修饰与生物学评价以及基于活性天然产物模板的创新药物研究。
2.活性分子合成导向的催化有机反应方法学研究：
以有机化学为基础，以复杂活性天然分子、活性先导化合物以及现有药物的高效、绿色合成为目标，开展活性分子合成导向的不对称催化反应方法学研究。

1、科研项目
(1) 国家“重大新药创制”科技重大专项（候选药物）（2009ZX09103-128）
(2) 国家自然科学基金 (20902111、21272276、21572272、22071267)
(3) 教育部新世纪优秀人才支持计划 （NCET-2008)
(4) 教育部霍英东基金基础性研究课题（121040）
(5) 江苏省高等学校优秀科技创新团队（2019）
2、学术获奖
(1) 2019年获批“江苏省高校优秀科技创新团队”（天然产物创新药物研究，团队带头人：姚和权）；
(2) 2011年度教育部“长江学者和创新团队发展计划”创新团队。

1.Qiuyu LiФ, Xinxin FangФ, Rui Pan, Hequan Yao*, Aijun Lin*, Palladium-catalyzed asymmetric sequential hydroamination of 1,3-enynes: enantioselective syntheses of chiral imidazolidinones. J. Am. Chem. Soc. 2022, 144, 11364-11376. (Фequal contribution, IF = 16.383)
2.Chunhua Han, Libo Cai, Dongquan Zhang, Rui Pan, Qiuyu Li, Aijun Lin*, Hequan Yao*. Site-selective palladium-catalyzed 1,1-arylamination of terminal alkenes. CCS Chem. 2022, 4, 616-624.
3.Dongquan Zhang, Miaomiao Li, Jiajia Li, Aijun Lin*, Hequan Yao*. Rhodium-catalyzed intermolecular enantioselective Alder–ene type reaction of cyclopentenes with silylacetylenes. Nat. Commun. 2021, 12, 6627-6633. (IF = 14.919)
4.Zhenbo Yuan, Yuye Zeng, Ziwen Feng, Zhe Guan, Aijun Lin*, Hequan Yao*. Constructing chiral bicyclo[3.2.1]octanes via palladium-catalyzed asymmetric tandem Heck/carbonylation desymmetrization of cyclopentenes. Nat. Commun. 2020, 11, 2544-2551. (IF = 12.121)
5.Zhenbo Yuan, Ziwen Feng, Yuye Zeng, Xiaobin Zhao, Aijun Lin*, Hequan Yao*. Palladium‐catalyzed asymmetric intramolecular reductive Heck desymmetrization of cyclopentenes: access to chiral bicyclo[3.2.1]octanes. Angew. Chem. Int. Ed. 2019, 58, 2884-2888. (IF = 12.257)
6.Chunhua Han, Zhiyuan Fu, Songjin Guo, Xinxin Fang, Aijun Lin*, Hequan Yao*. Palladium-catalyzed remote 1,n‑arylamination of unactivated terminal alkenes. ACS Catal. 2019, 9, 4196-4202. (IF = 12.221)
7.Youla Su, Haipin Zhou, Jiaxuan Chen, Jinyi Xu, Xiaoming Wu, Aijun Lin*, Hequan Yao*. Solvent-controlled switchable C-H alkenylation of 4-aryl 1H-pyrrole 3-carboxylates: application to the total synthesis of (±)-rhazinilam. Org. Lett. 2014, 16, 4884-4887. (IF = 6.324)
8.Lei Zhao, Ziyuan Li, Lin Chang, Jinyi Xu, Hequan Yao*, Xiaoming Wu*. Efficient construction of fused indolines with 2-quaternary center via intramolecular Heck reaction with low catalyst loading. Org. Lett. 2012, 14, 2066-2069. (IF = 5.558)
9.Hequan YaoФ, Min-Kyung SoФ, Jianghong Rao*. A bioluminogenic substrate for in vivo imaging of β-lactamase activity. Angew. Chem. Int. Ed. 2007, 46, 7031-7034. (Фequal contribution, IF = 10.031)
10.Hequan Yao, Yan Zhang, Fei Xiao, Zuyong Xia, Jianghong Rao*. A QD-BRET-based highly sensitive detection of protease. Angew. Chem. Int. Ed. 2007, 46, 4346-4349. (IF = 10.031)